PhD supervisor: Prof. Gebhard Schertler
SO = Scientific Objectives;
TO = Training Objectives.
SO1: Produce & characterise nanocrystals of bovine rhodopsin. Perform diffraction studies using microfocus beams and XFEL radiation.
SO2: Induce photoisomerization process in rhodopsin nanocrystals using a femtosecond pump laser & characterize early photoproducts with an XFEL.
TO1: Training in membrane protein biochemistry, purification & crystallisation.
TO2: Training in the use of fast lasers & time-resolved X-ray diffraction.
TO3: Biophysical characterisation & structure determination of membrane proteins.
Preparing nanocrystals of bovine rhodopsin in large quantities. The ESR will participate in biophysical characterisation of the nano-crystals with nanofocus beamline, time-resolved WAXS and diffraction studies at synchrotron radiation sources and at XFELs. The ESR will learn to use lasers to trigger isomerization reactions and analyse the reaction products by a time-resolved optical spectroscopy.
Involvement with other tasks: Assist others with the development of tools for membrane protein crystallisation and nano-crystallisation, biophysical characterisation and with diffraction data analysis from nano-crystals.
Local Training: Local Training: This ESR will be enrolled as a PhD student at the ETH Zurich, offering a range of courses in English including presentation, interview, supervision skills, and scientific ethics.
Bachelors degree in biotechnology (engineering) from SRM University, Chennai, India
Masters studies in Cancer Cell and Molecular Biology (MSc) from the University of Leicester, UK.
MSc project on the characterisation of potential HDAC inhibitors and identification of novel interactions within the Nucleosome Remodelling and histone Deacetylase Complex (MSc dissertation; University of Leicester).