PhD supervisor: Dr Margareta Ek
Objectives:SO = Scientific Objectives;
TO = Training Objectives.
SO1: Grow microcrystals of membrane proteins for XFEL based studies.
SO2: Solve structures of membrane proteins with bound inhibitors.
SO3: Evaluate fragment assisted drug discovery to find starting points on membrane proteins.
TO1: Training in membrane protein biochemistry, purification and crystallisation.
TO2: Training in the use of state-of-the art X-ray sources.
TO3: Training in structure based drug-design in an industrial context.
Growing membrane protein nano-crystals of membrane proteins for data collection and analysis using synchrotron and XFEL radiation. This work will lead onto structural studies of these membrane proteins with bound inhibitors so as to contribute to drug-development projects. This student will be educated in the tools of advanced X-ray diffraction in an industrial context.
Involvement with other tasks: Assist other partners in developing the field and to contribute to the research within pharmaceutical companies.
Local Training: This ESR will be enrolled as a PhD student at the University of Gothenburg where many courses are given in English (structural biology, protein engineering, computing etc.). The Academic supervisor will be Dr. Gisela Branden (UGOT)PUBLICATIONS
MraY–antibiotic complex reveals details of tunicamycin mode of action
Hakulinen J.K., Hering J., Brändén G., Chen H., Snijder A., Ek M., Johansson K
Published online– PMID: 28068312 DOI: 10.1038/nchembio.2270
BSc Technische Universität Darmstadt, Germany, in Biosciences
MSc Johann Wolfgang Goethe-Universität Frankfurt am Main, Germany, in Biophysics
MSc project “Production and purification of the voltage-gated ion channel KvAP“(University of Gothenburg)
Student project „Recombinant production, purification and crystallization of a bd-type quinol oxidase“(Max-Planck-Institute of Biophysics)
BSc project“ Production, purification and functional characterisation of the G protein coupled receptor binding angiotensin II“(Max-Planck-Institute of Biophysics)